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PMS2 Rabbit Monoclonal antibody

PMS2 Rabbit Monoclonal antibody

242455F8, EC:3.1.-.-, HNPCC4, PMS1 protein homolog 2, PMS2CL

货号：
RM20274
规格：

20ul

50ul

100ul

150ul
价格：
￥0.00

产品说明书

产品参数

产品类型	Monoclonal
基因名称	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
经测试应用	WB, IHC
宿主	Rabbit
种属反应性	Human
免疫原	A synthesized peptide derived from human PMS2
理论分子量	96 kDa
实际分子量	100-110 kDa
Gene ID(NCBI)	5395
GeneBank Accession Number	BC093921
UNIPROT	P54278
形式	Liquid
保存条件	Store at -20℃. Stable for one year after shipment. Aliquoting is unnecessary for -20℃ storage.
推荐稀释比例	WB：1:1000-1:5000
背景信息	The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome.

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