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VEGFA Recombinant antibody

VEGFA Recombinant antibody

货号：
RM20185
规格：

20ul

50ul

100ul
价格：
￥0.00

产品说明书

产品参数

别名	VEGF, 7H10, L-VEGF, N-VEGF, Vascular Endothelial Growth Factor
产品类型	Monoclonal
基因名称	vascular endothelial growth factor A
经测试应用	WB, IF/ICC
宿主	Rabbit
种属反应性	Human, Mouse
免疫原	A synthesized peptide derived from human VEGFA
理论分子量	46 kDa
实际分子量	35-40 kDa
Gene ID(NCBI)	7422
GeneBank Accession Number	‍‍BC065522‍
UNIPROT	P15692
形式	Liquid
保存条件	Store at -20℃. Stable for one year after shipment. Aliquoting is unnecessary for -20℃ storage.
推荐稀释比例	1:500-1:2500
背景信息	This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. The levels of VEGF are increased during infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), thus promoting inflammation by facilitating recruitment of inflammatory cells, and by increasing the level of angiopoietin II (Ang II), one of two products of the SARS-CoV-2 binding target, angiotensin-converting enzyme 2 (ACE2). In turn, Ang II facilitates the elevation of VEGF, thus forming a vicious cycle in the release of inflammatory cytokines.

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