| 别名 | 2F11, EC:2.3.1.-, EC:2.3.1.286, hSIR2, hSIRT1 |
| 产品类型 | Monoclonal |
| 基因名称 | sirtuin (silent mating type information regulation 2 homolog) 1 |
| 经测试应用 | WB, IF/ICC |
| 宿主 | Rabbit |
| 种属反应性 | Human |
| 免疫原 | A synthesized peptide derived from human SIRT1 |
| 理论分子量 | 82 kDa |
| 实际分子量 | 120 kDa |
| Gene ID(NCBI) | 23411 |
| GeneBank Accession Number | BC012499 |
| UNIPROT | Q96EB6 |
| 形式 | Liquid |
| 保存条件 | Store at -20℃. Stable for one year after shipment. Aliquoting is unnecessary for -20℃ storage. |
| 推荐稀释比例 | 1:500-1:4000 |
| 背景信息 | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. |