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Caspase8/P43/P18 Polyclonal antibody

Caspase8/P43/P18 Polyclonal antibody

货号：
AP20182
规格：

20ul

50ul

100ul
价格：
￥0.00

产品说明书前往锐竞购买

产品参数

别名	CASP8, Caspase 8, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4
产品类型	Polyclonal
基因名称	caspase 8, apoptosis-related cysteine peptidase
经测试应用	WB, IHC, IF/ICC
宿主	Rabbit
种属反应性	Human, Mouse
免疫原	A synthesized peptide derived from human Caspase 8
理论分子量	62 kDa
实际分子量	53-57 kDa, 28-34 kDa
Gene ID(NCBI)	841
GeneBank Accession Number	‍‍‍BC028223‍
UNIPROT	‍‍‍Q14790
形式	Liquid
保存条件	Store at -20℃. Stable for one year after shipment. Aliquoting is unnecessary for -20℃ storage.
推荐稀释比例	1:250-1:500
背景信息	This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.

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