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P16-INK4A Polyclonal antibody

P16-INK4A Polyclonal antibody

货号：
AP20120
规格：

20ul

50ul

100ul
价格：
￥0.00

产品说明书前往锐竞购买

产品参数

别名	p16, p16 INK4, P16 INK4A, p16-INK4, p16INK4A
产品类型	Polyclonal
基因名称	cyclin-dependent kinase inhibitor 2A
经测试应用	WB, IHC, FC
宿主	Rabbit
种属反应性	Human
免疫原	A synthesized peptide derived from human P16-INK4A
理论分子量	16 kDa
实际分子量	16 kDa
Gene ID(NCBI)	1029
GeneBank Accession Number	BC021998
UNIPROT	P42771
形式	Liquid
保存条件	Store at -20℃. Stable for one year after shipment. Aliquoting is unnecessary for -20℃ storage.
推荐稀释比例	1:1000-1:3000
背景信息	This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.

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