| 别名 | CD279, PD1, PD-1, 4H4D1, hPD 1 |
| 产品类型 | Monoclonal |
| 基因名称 | programmed cell death 1 |
| 经测试应用 | WB, IHC, IF-P |
| 宿主 | Mouse |
| 种属反应性 | Human, Mouse, Rat |
| 免疫原 | A synthesized peptide derived from human PD-1 |
| 理论分子量 | 32 kDa |
| 实际分子量 | 34 kDa |
| Gene ID(NCBI) | 5133 |
| GeneBank Accession Number | BC074740 |
| UNIPROT | Q15116 |
| 形式 | Liquid |
| 保存条件 | Store at -20℃. Stable for one year after shipment. Aliquoting is unnecessary for -20℃ storage. |
| 推荐稀释比例 | 1:2500-1:25000 |
| 背景信息 | Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. |