| 别名 | P53, Tumour Protein p53, Tumor suppressor p53, tumor protein p53, Antigen NY-CO-13 |
| 产品类型 | Monoclonal |
| 基因名称 | tumor protein p53 |
| 经测试应用 | WB, IHC, IF/ICC |
| 宿主 | Mouse |
| 种属反应性 | Human,Rat |
| 免疫原 | A synthesized peptide derived from human P53 |
| 理论分子量 | 53 kDa |
| 实际分子量 | 53 kDa |
| Gene ID(NCBI) | 7157 |
| GeneBank Accession Number | BC003596 |
| UNIPROT | P04637 |
| 形式 | Liquid |
| 保存条件 | Store at -20℃. Stable for one year after shipment. Aliquoting is unnecessary for -20℃ storage. |
| 推荐稀释比例 | 1:2500-1:25000 |
| 背景信息 | This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). |