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STAT3 Monoclonal antibody

STAT3 Monoclonal antibody

货号：
AM20112
规格：

20ul

50ul

100ul
价格：
￥0.00

产品说明书前往锐竞购买

产品参数

别名	3G2D12, Acute-phase response factor, APRF, HIES, STAT 3
产品类型	Monoclonal
基因名称	STAT3
经测试应用	WB, IHC, IF/ICC
宿主	Mouse
种属反应性	Human
免疫原	A synthesized peptide derived from human STAT3
理论分子量	88 kDa
实际分子量	75-88 kDa
Gene ID(NCBI)	6774
GeneBank Accession Number	BC000627
UNIPROT	P40763
形式	Liquid
保存条件	Store at -20℃. Stable for one year after shipment. Aliquoting is unnecessary for -20℃ storage.
推荐稀释比例	1:300-1:3000
背景信息	The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome.

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