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GPX4 Monoclonal antibody

GPX4 Monoclonal antibody

货号：
AM20105
规格：

20ul

50ul

100ul
价格：
￥0.00

产品说明书前往锐竞购买

产品参数

别名	GSHPx 4, GPx-4, GPx 4
产品类型	Monoclonal
基因名称	glutathione peroxidase 4 (phospholipid hydroperoxidase)
经测试应用	WB, IHC, IF/ICC
宿主	Mouse
种属反应性	Human, Mouse, Rat
免疫原	A synthesized peptide derived from human GPX4
理论分子量	22 kDa
实际分子量	17 kDa
Gene ID(NCBI)	2879
GeneBank Accession Number	BC021567
UNIPROT	P36969
形式	Liquid
保存条件	Store at -20℃. Stable for one year after shipment. Aliquoting is unnecessary for -20℃ storage.
推荐稀释比例	1:1000-1:4000
背景信息	The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Transcript variants resulting from alternative splicing or use of alternate promoters have been described to encode isoforms with different subcellular localization.

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