| 别名 | G3PD, GAPD, GAPDH, OK/SW cl.12 |
| 产品类型 | 内参抗体 |
| 基因名称 | glyceraldehyde-3-phosphate dehydrogenase |
| 经测试应用 | WB, IF/ICC |
| 宿主 | Mouse |
| 种属反应性 | Human, Mouse, Rat, Pig |
| 免疫原 | A synthesized peptide derived from human GAPDH |
| 克隆类型 | Monoclonal |
| 理论分子量 | 36 kDa |
| 实际分子量 | 36 kDa |
| Gene ID(NCBI) | 2597 |
| GeneBank Accession Number | BC004109 |
| UNIPROT | P04406 |
| 形式 | Liquid |
| 保存条件 | Store at -20℃. Stable for one year after shipment. Aliquoting is unnecessary for -20℃ storage. |
| 推荐稀释比例 | 1:25000-1:250000 |
| 背景信息 | This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. |