Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176)是一种有效的HDAC1和HDAC2抑制剂，无细胞试验中IC50分别为36 nM和47 nM。Romidepsin (FK228/depsipeptide) 在神经母细胞瘤肿瘤细胞中可控制生长并诱导凋亡。
| CAS No. | 128517-07-7 |
| 生物活性 | Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC50s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively. Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis. |
| 分子式 | C24H36N4O6S2 |
| 分子量 | 540.70 |
| 储存条件 | Powder -20℃ 3 years |
| 溶解性数据 | DMSO : ≥ 100 mg/mL (184.95 mM) |
| 体内研究 | Romidepsin (intraperitoneal injection; 0.5 and 1 mg/kg; every 3 day; 21 days) inhibited the tumor growth, reveals a higher expression of p-cdc25C, ki67, c-caspase-3 and c-PARP, and a lower expression of Ki-67 in Romidepsin treated tumors . |
| 体外研究 | Romidepsin (0-72 hours; 0-80 nM) inhibits proliferation of HCC cells in dose-dependent manner. Romidepsin (0-48 hours; 0-60 nM) leads to a time- and dose-dependent induction of cell cycle arrest in the G2/M phase in HCC cells. Romidepsin (0-48 hours; 0-60 nM) promotesapoptosis in HCC cells, increases c-caspase-3, c-caspase-9, and c-PARP protein expression. |
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| 纯度及产品资料 | 98% |
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