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抑制剂/激活剂

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凋亡与自噬

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4-Hydroxytamoxifen

4-Hydroxytamoxifen 4-羟基他莫昔芬; (Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen; (Z)-Afimoxifene

4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) 是一种口服有效，选择性的雌激素受体调节剂 (SERM)。

货号：
TK0621
规格：

1mg

5mg

10mg

25mg
价格：
￥0.00

产品参数

CAS No.	68047-06-3
生物活性	4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) is an orally active, selective estrogen receptor modulator (SERM).
分子式	C26H29NO2
分子量	387.51
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : 50 mg/mL (129.03 mM; ultrasonic and warming and heat to 60°C) Ethanol : 20 mg/mL (51.61 mM; Need ultrasonic)
体内研究	4-Hydroxytamoxifen (0.2, 1 and 5 μg/day, p.o.) causes a dose-related decrease in uterine wet weight of immature rats. 4-Hydroxytamoxifen (6 μg/0.1 mL sesame oil/day, s.c.) effectively attenuates methamphetamine-induced nigrostriatal dopamine depletions in bothsexes of intact and gonadectomized C57BL/6 J mice. 4-Hydroxytamoxifen does not alter the dopamine content levels in the striatum.
体外研究	4-Hydroxytamoxifen (Monohydroxytamoxifen) is a selective ostrogen receptor antagonist, with an IC50 of 3.3 nM for the [H]oestradiol binding to oestrogen receptor. 4-Hydroxytamoxifen (10, 100 nM) enables to inhibit the binding of [H]oestradiol to the human 8 S oestrogen receptor. 4-Hydroxytamoxifen activates intein-linked inactive Cas9, reduces off-target CRISPR-mediated gene editing. In human cells, conditionally active Cas9s modify target genomic sites with up to 25-fold higher specificity than wild-type Cas9.
文献	•Mol Cell. 2020 Aug 6;79(3):425-442.e7. •Nat Commun. 2018 Sep 25;9(1):3923. •Cell Death Dis. 2021 May 18;12(6):509. •Cell Death Dis. 2019 Sep 20;10(10):700. •Cell Death Dis. 2019 Sep 20;10(10):700. •Chin Med-UK. 2020 Mar 10;15:23. •J Mol Med (Berl). 2019 Aug;97(8):1183-1193.
纯度及产品资料	98%

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