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抑制剂/激活剂

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凋亡与自噬

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G15

G15 是一种高亲和力和选择性 G 蛋白偶联雌激素受体 (GPER/GPR30) 拮抗剂，Ki 值为 20 nM。

货号：
TK0618
规格：

1mg

5mg

10mg

50mg
价格：
￥0.00

产品参数

CAS No.	1161002-05-6
生物活性	G15 is a high affinity and selective G-protein-coupled estrogen receptor (GPER/GPR30) antagonist with a Ki of 20 nM.
分子式	C19H16NO2Br
分子量	370.24
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	-20°C, protect from light, stored under nitrogen
溶解性数据	DMSO : 41.67 mg/mL (112.55 mM; Need ultrasonic)
体内研究	G15 (1.46 mg/kg; i.h.; twice a week for 14 weeks) decreases the number of tumor nodules and tumor index increased by the E2 or G1 group in urethane-induced adenocarcinoma mice.
体外研究	G15 (0.1-10 μM; 2 days) inhibits GPER-mediated proliferation stimulated by 17β-estradiol (E2) in A549 and H1793 cell lines. G15 (1 μM; 48 hours) inhibits the response of GPER stimulated by E2 and G1 in A549 and H1793 cell lines.
文献	•Environ Pollut. 2021 Jan 1;268(Pt B):115748. •Biochem Pharmacol. 2021 Aug 4;192:114721. •J Clin Endocrinol Metab. 2021 Feb 1;dgab020. •J Histotechnol. 2021 Mar;44(1):27-36.
纯度及产品资料	98%

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