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G-418 disulfate

G-418 disulfate Geneticin sulfate; Antibiotic G-418 sulfate

G-418 disulfate (Geneticin sulfate) 是一种氨基糖苷类抗生素，抑制真核生物和原核生物的蛋白质合成。G-418 disulfate 是一种常用的真核细胞选择性药剂。

货号：
TK0613
规格：

10mg

25mg

500mg
价格：
￥0.00

产品参数

CAS No.	108321-42-2
生物活性	G-418 disulfate (Geneticin sulfate), is an aminoglycoside antibiotic, inhibits protein synthesis in eukaryotes and prokaryotes. G-418 disulfate is commonly used as a selective agent for eukaryotic cells.
分子式	C20H44N4O18S2
分子量	692.71
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	4°C, stored under nitrogen, away from moisture
溶解性数据	H2O : 125 mg/mL (180.45 mM; Need ultrasonic)
体外研究	G418 sulfate, an aminoglycoside neomycin analogue, interferes with protein synthesis and has been used extensively for selection of mammalian cell lines that possess neomycin resistance (NR). The neomycin resistance (neo) gene is frequently used in eukaryotic vectors as a dominant selectable gene. G418 can be covalently bound to asialoorosomucoid (AsOR) to form a conjugate for hepatocyte-specific targeting and toxicity. The human GD3 synthase cDNA was transfected into MDA-MB231 cells, and G-418 bulk selection was used to select cells stably overexpressing the GD3 synthase. An aminoglycoside antibiotic, G418, has been shown to be an inhibitor of many pro- and eukaryotes at concentrations from 1-300 microgram/ml.
文献	•Cell Death Differ. 2020 Jun;27(6):1981-1997. •Cell Rep. 2021 Sep 21;36(12):109739. •Cell Rep. 2021 Mar 30;34(13):108906. •Cell Rep. 2020 Oct 20;33(3):108287. •Cell Death Dis. 2020 Jun 4;11(6):420. •Cell Death Dis. 2019 May 28;10(6):413. •Am J Cancer Res. 2021 May 15;11(5):2062-2080. •J Genet Genomics. 2021 Mar 30. •Med Oncol. 2021 Nov 10;39(1):10. •Research Square Preprint. 2021 Nov. •Research Square Preprint. 2020 Jun.
纯度及产品资料	98%

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