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抑制剂/激活剂

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凋亡与自噬

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AVE 0991

AVE 0991 是一种有效的非肽Ang-(1-7) 受体 Mas 激动剂。AVE 0991 与 [125I]-Ang-(1-7) 竞争性地结合到牛主动脉内皮细胞膜，IC50 为 21 nM。

货号：
TK0597
规格：

1mg

2mg

5mg

10mg
价格：
￥0.00

产品参数

CAS No.	304462-19-9
生物活性	AVE 0991 is a nonpeptide and orally active angiotensin-(1-7) receptor agonist with an IC50 of 21 nM.
分子式	C29H32N4O5S2
分子量	580.72
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : 41.67 mg/mL (71.76 mM; Need ultrasonic)
体内研究	AVE 0991 (0.58 nmol/g) produces a significant decrease of water diuresis in WT mice compared with vehicle-treated animals (0.06±0.03 mL versus 0.27±0.05; n=9 for each group; P<0.01). The antidiuretic effect of AVE 0991 (AVE) is associated with an increase in urine osmolality (1669±231.0 mOsm/KgH2O versus 681.1±165.8 mOsm/KgH2O in vehicle-treated mice; P<0.01). The genetic deletion of Mas abolishes the antidiuretic effect of AVE 0991 during water loading (0.37±0.10 mL [n=9] versus 0.27±0.03 mL [n=11] in AVE 0991-treated mice). As observed with C57BL/6 mice, administration of AVE 0991 (0.58 nmol/g) in water-loaded Swiss mice also produces a significant decrease of the urinary volume compared with vehicle-treated animals (0.13±0.05 mL [n=16] versus 0.51±0.04 mL [n=40]; P<0.01). One week of treatment with AVE-0991 produces a significant decrease in perfusion pressure (56.55±0.86 vs. 68.73±0.69 mmHg in vehicle-treated rats) and an increase in systolic tension (11.40±0.05 vs. 9.84±0.15 g in vehicle-treated rats), rate of tension rise (+dT/dt; 184.30±0.50 vs. 155.20±1.97 g/s in vehicle-treated rats), rate of tension fall (−dT/dt; 179.60±1.39 vs. 150.80±2.42 g/s in vehicle-treated rats). A slight increase in heart rate (HR) is also observed (220.40±0.71 vs. 214.20±0.74 beats/min in vehicle-treated rats.
体外研究	AVE 0991 is a nonpeptide compound that evokes effects similar to Ang-(1-7) on the endothelium. AVE 0991 and unlabeled Ang-(1-7) compete for high-affinity binding of [I]-Ang-(1-7) to bovine aortic endothelial cell membranes with IC50s of 21±35 and 220±280 nM, respectively. Peak concentrations of NO and O2 release by AVE 0991 sodium salt and Ang-(1-7) (both 10 μM) are not significantly different (NO: 295±20 and 270±25 nM; O2: 18±2 and 20±4 nM). However, the released amount of bioactive NO is ≈5 times higher for AVE 0991 in comparison to Ang-(1-7).
文献	•Blood. 2015 Jan 22;125(4):710-9. •Redox Biol. 2019 Jan;20:75-86. •Diabetes. 2017 Aug;66(8):2201-2212. •J Inflamm Res. 2021 Dec 18;14:7007-7019. •Front Aging Neurosci. 2021 Feb 15. •Aging (Albany NY). 2018 Apr 17;10(4):645-657. •PLoS One. 2015 Nov 5;10(11):e0142087. •Research Square Preprint. 2021 Nov.
纯度及产品资料	98%

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