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抑制剂/激活剂

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凋亡与自噬

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CCG-1423

CCG-1423是一种新型的RhoA/C介导的基因转录抑制剂，能抑制细胞的转移前列腺癌PC-3细胞侵袭模型。

货号：
TK0587
规格：

1mg

5mg

10mg

50mg

100mg
价格：
￥0.00

产品参数

CAS No.	285986-88-1
生物活性	CCG-1423 is a novel inhibitor of RhoA/C-mediated gene transcription that is capable of inhibiting invasion of PC-3 prostate cancer cells in a Matrigel model of metastasis. IC50 value: 1.5 uM [1] Target: Rho signaling inhibitor in vitro: CCG-1423 selectively inhibited spontaneous PC-3 prostate cancer cell invasion through a Matrigel matrix, but not the Gαi-dependent LPA-stimulated SKOV-3 ovarian cancer cell invasion, in vitro. At 100 μM, nearly complete inhibition of invasion was achieved with a lesser degree of toxicity than that induced by CCG-1423 at 10 μM [1]. SRF binds to this site in vivo and the SRF inhibitor CCG-1423 completely blocks STARS proximal reporter activity in H9c2 cells [3]. pharmacological MKL-inhibition with CCG-1423 significantly inhibited CCN1 promoter activity as well as mRNA and protein expression[4]. in vivo: Pharmacological SRF inhibition by CCG-1423 reduced nuclear MKL1 and improved glucose uptake and tolerance in insulin-resistant mice in vivo [2].
分子式	C18H13ClF6N2O3
分子量	454.75
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : ≥ 26 mg/mL (57.17 mM)
文献	•Cell Biosci. 2021 Jan 28;11(1):25. •Cancers (Basel). 2020 Nov 27;12(12):3540. •Commun Biol. 2021 Mar 25;4(1):399. •Theriogenology. 2019 Oct 15;138:84-93. •Reprod Fertil Dev. 2020 Mar;32(5):522-530.
纯度及产品资料	98%

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