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抑制剂/激活剂

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凋亡与自噬

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Semaglutide 索马鲁肽

Semaglutide 是人胰高血糖素样肽-1 的一个长效类似物，是人胰高血糖素样肽-1 (GLP-1) 受体的激动剂。Semaglutide 有潜力用于 2 型糖尿病的研究。

货号：
TK0569
规格：

500ug

1mg

5mg
价格：
￥0.00

产品参数

CAS No.	910463-68-2
生物活性	Semaglutide, a long-acting GLP-1 analogue, is a glucagon-like peptide-1 (GLP-1) receptor agonist. Semaglutide has the potential for type 2 diabetes treatment.
分子式	C187H291N45O59
分子量	4113.64
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	H2O : 50 mg/mL (12.15 mM; Need ultrasonic) DMSO : 33.33 mg/mL (8.10 mM; Need ultrasonic)
体内研究	The plasma half-life of Semaglutide is 46h in mini-pigs following i.v. administration and semaglutide has an MRT of 63.6h after s.c. dosing to mini-pigs. Semaglutide improves 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced motor impairments. In addition, Semaglutide rescues the decrease of tyrosine hydroxylase (TH) levels, alleviates the inflammation response, reduces lipid peroxidation, inhibits the apoptosis pathway, and also increases autophagy- related protein expression, to protect dopaminergic neurons in the substantia nigra and striatum. Moreover, the long-acting GLP-1 analogue semaglutide is superior to NN-2211 in most parameters.
体外研究	Semaglutide has two amino acid substitutions compared to human GLP-1 (Aib, Arg) and is derivatized at lysine 26. The GLP-1R affinity of Semaglutide is 0.38±0.06 nM. Semaglutide is a GLP-1 analogue with 94% sequence omology to human GLP-1.
文献	•Int J Mol Med. 2021 Dec;48(6):219.
纯度及产品资料	98%

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