>>

>>

抑制剂/激活剂

>>

凋亡与自噬

>>

Aprotinin 抑肽酶；抑胰肽酶；屈来密多

Aprotinin是一种丝氨酸蛋白酶的抑制剂 (对bovine β-trypsin的Kd值为0.06 pM)，用于降低围手术期的失血和输血。

货号：
TK0533
规格：

10mg

50mg

100mg
价格：
￥0.00

产品参数

CAS No.	9087-70-1
生物活性	Aprotinin is a bovine pancreatic trypsin inhibitor (BPTI) inhibitor which inhibits trypsin and chymotrypsin with Kis of 0.06 pM and 9 nM, respectively.
分子式	C284H432N84O79S7
分子量	6511.44
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder, -20°C ,3 years
溶解性数据	H2O : 100 mg/mL (15.36 mM; Need ultrasonic)
体内研究	High dose aprotinin can reduce blood loss and transfusion requirements associated with primary cardiac procedures such as coronary artery bypass graft (CABG) or heart valve replacement surgery. Aprotinin inhibits thrombus formation in a dose-dependent manner. Aprotinin at a dose of 1.5 mg kg (bolus) and 3 mg kg h infusion (maintenance infusion) causes a tendency towards a reduction in bleeding time. Aprotinin significantly reduces the bleeding time starting at a dose of 3 mg kg bolus plus 6 mg kg h showing a reduction of approximately 84%±2.9%. At the highest dose of 5 mg kg and 10 mg kg h, the strongest effects are observed. Aprotinin may affect tumor necrosis factor-alpha (TNF) levels. Soluble TNFRI levels are significantly increased following I/R in the aprotinin treated wild type mice and not detected in all TNFRInull mice.
体外研究	Aprotinin, a serine protease inhibitor isolated from bovine lung, is a complex protease inhibitor that is an antifibrinolytic, inhibits contact activation, and decreases the inflammatory response to cardiopulmonary bypass. Aprotinin inhibits trypsin (bovine, Ki= 0.06 pM), chymotrypsin (bovine, Ki= 9 nM), plasmin (human, 0.23 nM). Aprotinin is also a competitive protein inhibitor of NOS activity. It inhibits NOS-I and NOS-II with Ki values of 50 μM and 78 μM, respectively. Aprotinin significantly inhibits fibrinolysis with an IC50 of 0.16±0.05 μM.
纯度及产品资料	98%

推荐产品