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抑制剂/激活剂

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凋亡与自噬

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PMSF Phenylmethylsulfonyl fluoride

PMSF (Phenylmethylsulfonyl Fluoride, Benzylsulfonyl fluoride)是一种不可逆的丝氨酸/半胱氨酸蛋白酶抑制剂。

货号：
TK0520
规格：

25mg

100mg

500mg

1g
价格：
￥0.00

产品参数

CAS No.	329-98-6
生物活性	PMSF is an irreversible serine/cysteine protease inhibitor commonly used in the preparation of cell lysates.
分子式	C7H7O2FS
分子量	174.19
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder, -20°C ,3 years
溶解性数据	DMSO : 250 mg/mL (1435.21 mM; Need ultrasonic)，Isopropanol : 60 mg/mL (344.45 mM; Need ultrasonic)
体内研究	PMSF (0.1 mL/10 g b.wt, i.p.) produces antinociception as indicated by the dose-responsive increase in % MPE in the tail-flick latency evaluation, but fails to produce a clear dose-responsive inhibition of locomotion. Mice receiving i.p. injections of PMSF exhibit cannabinoid effects that includes antinociception, hypothermia and immobility with ED50 values of 86, 224 and 206 mg/kg, respectively. PMSF (30 mg/kg) pretreatment potentiates the effects of anandamide on tail-flick response (antinociception), spontaneous activity and mobility by 5-, 10- and 8-fold, respectively.
体外研究	PMSF (2 mM) inhibits carbachol-stimulated inositol phosphate accumulation in the presence of Li by only 15%-19%. PMSF inhibition of phosphoinositide turnover is due to one or more steps following phosphoinositide breakdown. PMSF inhibits the acylation of the inositol residue of GPI intermediates in bloodstream form T. brucei. PMSF inhihits the formntion of glycolipid C but does not inhibit fatty acid remodeling in vitro. PMSF inhihits GPI acylation and ethanolamine phosphatp addition in procyclic trypanosomes but not in Hela cells.
纯度及产品资料	98%

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