Cytochalasin D (Zygosporin A; NSC 209835) 是一种有效、细胞渗透性的肌动蛋白聚合抑制剂，由真菌产生，通过绑定 G-actin 抑制 G-actin–cofilin 的相互作用。Cytochalasin D 还能抑制 cofilin 与 F-actin 的结合，降低了活细胞中肌动蛋白聚合和解聚的速率。Cytochalasin D 可以减少外泌体的释放，进而减少肿瘤环境中 survivin 的量。 Cytochalasin D 诱导 YAP 磷酸化，阻止其核易位保留在胞质中。
| CAS No. | 22144-77-0 |
| 生物活性 | Cytochalasin D (Zygosporin A; NSC 209835) is a potent and cell-permeable inhibitor of actin polymerization derived from fungus, inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D (Zygosporin A; NSC 209835) also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells.Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of YAP. |
| 分子式 | C30H37NO6 |
| 分子量 | 507.62 |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存条件 | Powder -20°C 3 years |
| 溶解性数据 | DMSO : 100 mg/mL (197.00 mM; Need ultrasonic and warming) |
| 文献 | •Biomaterials. 13 January 2022, 121373. •Cell Mol Gastroenterol Hepatol. 2021;11(3):683-696. •Front Immunol. 2021 Jun 1;12:684430. •Stem Cell Res Ther. 2021 Oct 7;12(1):523. •Mat Sci Eng C-Mater. 2021, 111939. •Langmuir. 2020 Sep 29;36(38):11374-11382. •Virus Res. 2020 Jan 15;276:197806. |
| 纯度及产品资料 | 98% |
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