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抑制剂/激活剂

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凋亡与自噬

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Belumosudil KD025; SLx-2119

Belumosudil (KD025) 是一种选择性的 ROCK2 抑制剂，对 ROCK2 和 ROCK1 的 IC50 值分别为 105 nM 和 24 µM。具有抗纤维化特性。

货号：
TK0489
规格：

1mg

2mg

5mg

10mg

50mg
价格：
￥0.00

产品参数

CAS No.	911417-87-3
生物活性	Belumosudil (KD025) is a selective inhibitor of ROCK2 with IC50s of 105 nM and 24 µM for ROCK2 and ROCK1, respectively. Anti-fibrotic properties.
分子式	C26H24N6O2
分子量	452.51
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : 250 mg/mL (552.47 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble)
体内研究	Belumosudil (KD-025; 100, 200 or 300 mg/kg, i.p.) dose-dependently reduces infarct volume after transient middle cerebral artery occlusion. Belumosudil is at least as efficacious in aged, diabetic or female mice, as in normal adult males.
体外研究	Belumosudil (SLx-2119; 40 µM) induces significant down-regulations of Tsp-1 and CTGF mRNA levels in PASMC. The microarray hybridized with aRNA from HMVEC treated with Belumosudil, shows a 5-times higher background than the other arrays.
文献	•Am J Respir Cell Mol Biol. 2020 Oct;63(4):519-530. •J Autoimmun. 2018 May;89:125-138. •Neurobiol Dis. 2019 Apr;124:520-530. •Adipocyte. 2019 Dec;8(1):114-124. •Molecules. 2020 Mar 17;25(6):1369. •Sci Rep. 2018 Feb 6;8(1):2477. •PLoS One. 2017 May 16;12(5):e0177332. •JCI Insight. 2018 Jun 7;3(11). pii: 98921. •Patent. US20190298733A1. •Patent. US9937154B2. •Methods Mol Biol. 2018;1711:351-398. •Patent. US9687483B2. •Patent. US20160361300A1. •Patent. US20160346224A1. •Medizinische Fakultät, University Goettingen. 2016 Oct. •Patent. US20160213664A1.
纯度及产品资料	98%

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