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抑制剂/激活剂

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凋亡与自噬

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Go 6983 Gö 6983; Goe 6983

Go 6983 是一种有效的 PKC 抑制剂，能够作用于 PKCα，PKCβ，PKCγ，PKCδ 和 PKCζ，IC50 值分别为 7 nM，7 nM，6 nM，10 nM 和 60 nM。

货号：
TK0488
规格：

1mg

2mg

5mg

10mg
价格：
￥0.00

产品参数

CAS No.	133053-19-7
生物活性	Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ, PKCδ and PKCζ with IC50 of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.
分子式	C26H26N4O3
分子量	442.51
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : ≥ 34 mg/mL (76.83 mM)
体外研究	Go 6983 inhibits PKCμ with IC50 of 20 μM, and the pther PKC isoenzymes can be suppressed by Go 6983 with IC50 values from 7 to 60 nM. Go 6983 (100 nM) significantly reduces PMN adherence to the endothelium and infiltration into the myocardium compared with I/R + PMN hearts, and significantly inhibits superoxide release from PMNs by 90 +/- 2% in rat hearts. Go 6983 (200 nM) has a reduced cardioprotective effect compared with the cardioprotective Go 6983 concentrations (50 and 100 nM) despite inhibiting PMN superoxide release by 99%.
文献	•Nature. 2021 Dec 2. •Immunity. 2021 Sep 14;54(9):2042-2056.e8. •Theranostics. 2021 Jan 1;11(6):2612-2633. •Acta Pharm Sin B. 2021 Jan;11(1):71-88. •Oncogene. 2021 Jul;40(30):4884-4893. •Exp Mol Med. 2021 Apr 2. •Cell Death Dis. 2021 Nov 27;12(12):1113. •Cell Death Dis. 2018 Feb 7;9(2):165. •Elife. 2021 Mar 3;10:e60889. •Free Radic Biol Med. 2021 Jun 8;S0891-5849(21)00353-1. •Front Oncol. 21 June 2021. •Food Funct. 2021 Mar 9. •J Cell Mol Med. 2021 May 5. •Cell Mol Neurobiol. 2020 Nov;40(8):1253-1269. •Sci Rep. 2017 Oct 19;7(1):13571. •Arch Biochem Biophys. 2020 Jul 15;687:108375. •J Nat Prod. 2021 Mar 16. •Cell Biol Int. 2020 Mar;44(3):838-847. •Biochem Biophys Res Commun. 2018 Sep 3;503(1):62-70. •J Appl Toxicol. 2016 Nov;36(11):1409-17. •Vet Microbiol. 2016 Aug 30;192:26-33. •Diabetes Metab Syndr Obes. 2019 Nov 4;12:2289-2302. •Theriogenology. 2019 Oct 15;138:84-93. •Reprod Fertil Dev. 2020 Mar;32(5):522-530. •Research Square Preprint. 2021 Oct. •Rep Biochem Mol Biol. 2021 Jul;10(2):314-326. •Reports of Biochemistry and Molecular Biology. 2021 Aug. •Harvard Medical School LINCS LIBRARY
纯度及产品资料	95%

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