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抑制剂/激活剂

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凋亡与自噬

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CNQX

CNQX (6-cyano-7-nitroquinoxaline-2,3-dione)是一种AMPA和kainate receptor拮抗剂，对AMPA和kainate recepto的IC50分别为0.3 μM和1.5 μM。CNQX也是NMDA受体复合物上甘氨酸调节位点的拮抗剂(IC50为25 μM)。CNQX在缺血模型中表现出神经保护作用，并抑制海马神经元的癫痫样活动。

货号：
TK0477
规格：

1mg

5mg

10mg

25mg
价格：
￥0.00

产品参数

CAS No.	115066-14-3
生物活性	CNQX (FG9065) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX is a competitive non-NMDA receptor antagonist. CNQX blocks the expression of fear-potentiated startle in rats.
分子式	C9H4N4O4
分子量	232.15
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder, -20°C ,3 years
溶解性数据	DMSO : 25 mg/mL (107.69 mM; Need ultrasonic)
体内研究	CNQX (FG9065; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices.CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments.
体外研究	CNQX (FG9065; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices.CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments.
纯度及产品资料	98%

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