AM 281 AM281 抑制剂

AM281 is a potent and selective central cannabinoid (CB) receptor antagonist/inverse agonist (Ks = 12 nM and 4,200 nM for CB and CB, respectively). Structurally, it is an analog of the CB inverse agonist rimonabant . It has no effect on the vanilloid TRPV1 receptor. AM281 has been used to evaluate the potential effects of compounds at CB It has also been used to study the membrane localization and cycling of CB