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抑制剂/激活剂

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凋亡与自噬

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Ketanserin 酮色林；凯坦色林；凯他色林；酮舍林；氟哌喹酮

Ketanserin (R41468, Ketanserinum) 是一种特异性的5-HT2A 5-羟色胺受体拮抗剂，作用于大鼠和人5-HT2A，Ki为2.5 nM。

货号：
TK0470
规格：

5mg

10mg

50mg

100mg
价格：
￥0.00

产品参数

CAS No.	74050-98-9
生物活性	Ketanserin is a selective 5-HT2 receptor antagonist. Ketanserin also blocks hERG current (IhERG) in a concentration-dependent manner (IC50=0.11 μM).
分子式	C22H22FN3O3
分子量	395.43
运输条件	Room temperature in continental US; may vary elsewhere.
溶解性数据	DMSO : 16.67 mg/mL (42.16 mM; Need ultrasonic),DMF : 5 mg/mL (12.64 mM; Need ultrasonic)
体内研究	Ketanserin is a 5-HT2A receptor antagonist. Ketanserin significantly reduces BDNF protein levels in numerous brain regions (CA1 and CA3 of the hippocampus, prefrontal cortex, central amygdaloid nucleus, dorsomedial hypothalamic nucleus, dentate gyrus, shell of the nucleus accumbens and midbrain periaqueductal gray). 5-HT2A antagonist Ketanserin can significantly reduce BDNF mRNA levels in various brain regions.
体外研究	Ketanserin at 0.3 μM inhibits the voltage-dependent step current (IhERG.step) and tail current (IhERG.tail) of hERG channels with a 5-min exposure. The synergistic effect observed for AA with 5-HT is, also, blocked by the 5-HT receptor blockers cyproheptadine (IC50=22.0±7 μM), Ketanserin (IC50=152±23 μM). Ketanserin (50-350 μM) inhibits the synergism by blocking the receptor in a dose-dependent manner. The IC50 value of Cyproheptadine is 22±7 μM and Ketanserin is 152±23 μM. Ketanserin inhibits platelet aggregation with an IC50 of 240 (169-339) nM.
纯度及产品资料	98%

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