Chlorpromazine (CPZ) 是一种低效的典型抗精神病药，用于治疗精神病如精神分裂症。Chlorpromazine (CPZ) 在体外可抑制 5-HT(2A) receptor 和 dopamine D2。Chlorpromazine (CPZ) 还可抑制 sodium channel，并阻断HERG potassium channels，对应的IC50值为21.6 μM。
| CAS No. | 50-53-3 |
| 生物活性 | Chlorpromazine is an antipsychotic agent that can be used for the research of psychotic disorders. Chlorpromazine interferes with several ligand and voltage-gated channels. Chlorpromazine is a potent dopamine antagonist. Chlorpromazine inhibits CYP1A2 and CYP2D6 activity with IC50s of 9.5 and 20 μM, respectively. Chlorpromazine induces autophagy but does not induce apoptosis. |
| 分子式 | C17H19ClN2S |
| 分子量 | 318.86 |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存条件 | Powder, -20°C ,3 years |
| 溶解性数据 | DMSO : 100 mg/mL (313.62 mM; Need ultrasonic) |
| 纯度及产品资料 | 98% |
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