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抑制剂/激活剂

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凋亡与自噬

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SANT-1

SANT-1 是一种有效的 Smo 拮抗剂，能够抑制 Hedgehog 通路，在 Shh-LIGHT2 和 SmoA1-LIGHT2 实验中，IC50 值分别为 20 nM 和 30 nM。

货号：
TK0458
规格：

1mg

5mg

10mg

50mg
价格：
￥0.00

产品参数

CAS No.	304909-07-7
生物活性	SANT-1, a potent Smo antagonist, inhibits Hedgehog signaling. SANT-1 shows IC50s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 assay, respectively.
分子式	C23H27N5
分子量	373.49
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : 62.5 mg/mL (167.34 mM; Need ultrasonic)
体外研究	SANT-1 is a potent Smo antagonist, binds directly to Smo, and inhibits Hedgehog signaling, with IC50s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 cells, respectively. SANT-1 (1 μM, for 24 or 48 hours) decreases the proliferation of medulloblastoma cells.
文献	•Front Cell Dev Biol. 13 May 2021.
纯度及产品资料	98%

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