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GJ103 sodium salt

GJ103 sodium salt

GJ103 sodium salt是通读化合物GJ072的活性类似物。

货号：
TK0425
规格：

1mg

5mg

10mg

25mg
价格：
￥0.00

产品参数

CAS No.	1459687-96-7
生物活性	GJ103 sodium salt is an active analog of the read-through compound GJ072.
分子量	364.35
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : ≥ 34 mg/mL (93.32 mM)
体内研究	GJ103 sodium salt is water soluble, making it much easier to work with in in vivo experiments.
体外研究	Chemical-induced read through of premature stop codons might be exploited as a potential treatment strategy for genetic disorders caused by nonsense mutations. GJ072 is a novel read-through compound (RTC). GJ072 shows activity comparable to stop codons (TGA, TAG, and TAA) PTC124 and RTC13. GJ072 induces ATM kinase on both TGA and TAG stop codons and restored ATMpSer1981 autophosphorylation and SMC1pSer966 transphosphorylation as measured by FACS. GJ072 is active in A-T cells with a homozygous TAA mutation. GJ072 is able to induce detectable full-length ATM protein in treated A-T cells. Early structure-activity relationship studies generates eight active analogs of GJ072. Some GJ072 analogs (e.g., GJ103, GJ106, GJ109, and GJ111) consistently demonstrates their activities in all three PTCs by both FCATMpSer1981 and IRIF assays. GJ071 and GJ072 and some of their analogs (such as GJ103) have similar read-through activity as RTC13 or RTC14, but are more tolerable than RTC13 and RTC14 to A-T cells. GJ103 does not show obvious cytotoxicity in A-T cells at concentration as high as 300 μM.
纯度及产品资料	98%

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