>>

>>

抑制剂/激活剂

>>

凋亡与自噬

>>

Duvelisib IPI-145; INK1197

Duvelisib (IPI-145, INK1197) 是一种新型选择性PI3K δ/γ抑制剂，在无细胞试验中Ki和IC50分别为 23 pM/243 pM 和 1 nM/50 nM，对 PI3K δ/γ 的选择性比对其它蛋白激酶高。Phase 3。

货号：
TK0419
规格：

1mg

2mg

5mg

10mg

25mg
价格：
￥0.00

产品参数

CAS No.	1201438-56-3
生物活性	Duvelisib (IPI-145) is a selectivite p100δ inhibitor with IC50 of 2.5 nM, 27.4 nM, 85 nM and 1602 nM for p110δ, P110γ, p110β and p110α, respectively.
分子式	C22H17ClN6O
分子量	416.86
储存条件	Powder -20℃ 3 years
溶解性数据	DMSO : 100 mg/mL (239.89 mM; ultrasonic and warming and heat to 60°C)
体外研究	PI3Kδ and PI3Kγ inhibition with Duvelisib (IPI-145) has anti-proliferative activity in primary AML cells by inhibiting the activity of AKT and MAPK. Pre-treatment of AML cells with Duvelisib inhibits both adhesion and migration of AML blasts to bone marrow stromal cells.
文献	暂无相关参考文献
纯度及产品资料	98%

推荐产品