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抑制剂/激活剂

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凋亡与自噬

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MHY1485

MHY1485是一种有效的，细胞渗透性 mTOR 激动剂，也能有效抑制 autophagy。

货号：
TK0409
规格：

1mg

5mg

10mg

50mg
价格：
￥0.00

产品参数

CAS No.	326914-06-1
生物活性	MHY1485 is a potent cell-permeable mTOR activator that targets the ATP domain of mTOR. MHY1485 inhibits autophagy by suppression of fusion between autophagosomes and lysosomes.
分子式	C17H21N7O4
分子量	387.39
储存条件	Powder -20℃ 3 years
溶解性数据	DMSO : 7.69 mg/mL (19.85 mM; Need ultrasonic) H2O : 1 mg/mL (2.58 mM; Need ultrasonic)
体内研究	MHY1485 (intraperitoneal injection; 10 mg/kg, 2 days) blocks the autophagy signaling induced by follicle-stimulating hormone (FSH). It increases p-mTOR and p-S6K1 expression levels, whereas LC3 expression shows no marked change compared to that in the control group.
体外研究	MHY1485 (10 μM; 4 hours) shows that GCDC-induced autophagic activity is inhibited by upregulating p-mTOR expression and downregulating LC3 and p62 expression in HCC cells. MHY1485 (5 μM; 6 hours) increases the LC3II/LC3I ratio in a dose and time-dependently manner due to presumably inhibited LC3II degradation in rat liver Ac2F cells. MHY1485 (0.5-2 μM; 6 hours) increases the phosphorylation of mTOR at ser2448 and upregulates the level of phosphorylation of 4E-BP1 in a dose-dependently manner in Ac2F cells.
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纯度及产品资料	98%

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