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抑制剂/激活剂

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凋亡与自噬

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AZ20

AZ20是一种新型有效的选择性ATR激酶抑制剂，无细胞试验中IC50为5 nM，比作用于mTOR的选择性高8倍。

货号：
TK0401
规格：

2mg

5mg

10mg

50mg
价格：
￥0.00

产品参数

CAS No.	1233339-22-4
生物活性	AZ20 is a potent and selective inhibitor of ATR with an IC50 of 5 nM, and has 8-fold selectivity against mTOR (IC50=38 nM).
分子式	C21H24N4O3S
分子量	412.51
储存条件	Powder -20℃ 3 years
溶解性数据	DMSO : ≥ 100 mg/mL (242.42 mM)
体内研究	AZ20 (25, 50 mg/kg, p.o.) has high permeability combined with good stability to rat hepatocytes and, despite the lack of progress in achieving markedly higher solubility, has respectable bioavailability in a low dose rat PK study. AZ20 (25, 50 mg/kg, p.o.) leads to significant tumor growth inhibition in female nude mice bearing LoVo tumors.
体外研究	AZ20 inhibits ATR immunoprecipitated from HeLa nuclear extracts with an IC50 of 5 nM and ATR mediated phosphorylation of Chk1 in HT29 colorectal adenocarcinoma tumor cells with an IC50 of 50 nM.
文献	暂无相关参考文献
纯度及产品资料	98%

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