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Chlorotrianisene

Chlorotrianisene 氯丁烯二烯

Chlorotrianisene (tri-p-anisylchloroethylene, TACE, CTA) 是一种合成的、非类固醇的雌激素。是选择性的雌激素受体调节剂。

货号：
TK0399
规格：

2mg

5mg

10mg
价格：
￥0.00

产品参数

CAS No.	569-57-3
生物活性	Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme COX-1 and inhibits platelet aggregation in whole blood.
分子式	C23H21ClO3
分子量	380.86
储存条件	Powder -20℃ 3 years
溶解性数据	DMSO : 100 mg/mL (262.56 mM; Need ultrasonic)
体内研究	The incubation of Chlorotrianisene with rat liver microsomes and NADPH generates a reactive intermediate which binds covalently to proteins. Intermediate may inactivate the uterine estrogen receptors (ER). The incubation of Chlorotrianisene with rat liver microsomes and NADPH in the presence of rat uteri, under conditions which generate intermediate, markedly decreased the binding capacity of the ER for [H]estradiol (E2).
体外研究	Comparison of intracellular estrogen receptor (ER) affinities of Chlorotrianisene with respective rat uterine cytosolic ER affinities has initially suggested the potential for activation of ER as a mechanism of growth stimulation. Chlorotrianisene exhibits concentration dependent cell growth stimulation with an EC50 of 28 nM and a Ki of 500 nM in MCF-7 cells.
文献	暂无相关参考文献
纯度及产品资料	98%

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