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抑制剂/激活剂

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凋亡与自噬

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Necrosulfonamide

Necrosulfonamide

Necrosulfonamide是一种特异的、有效的细胞坏死抑制剂，通过抑制MLKL发挥其作用。

货号：
TK0389
规格：

1mg

5mg

10mg

25mg
价格：
￥0.00

产品参数

CAS No.	1360614-48-7
生物活性	Necrosulfonamide is a necroptosis inhibitor acting by selectively targeting the mixed lineage kinase domain-like protein (MLKL). Necrosulfonamide prevents MLKL-RIP1-RIP3 necrosome complex from interacting with its downstream effectors. MLKL is a critical substrate of RIP3 during the induction of necrosis.
分子式	C18H15N5O6S2
分子量	461.47
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : ≥ 28 mg/mL (60.68 mM)
体外研究	Necrosulfonamide specifically blocks necrosis downstream of RIP3 activation. Necrosulfonamide inhibits MLKL-mediated necrosis by blocking Its N-terminal CC domain function.
文献	•Autophagy. 2021 Jul 20;1-19. •Cell Death Differ. 2021 Apr;28(4):1222-1236. •J Clin Invest. 2021 Nov 9;e151268. •Redox Biol. 2021, 101942. •Theranostics. 2020 Jun 19;10(17):7710-7729. •J Exp Clin Cancer Res. 2021 Jun 23;40(1):206. •J Invest Dermatol. 2021 Jul 6;S0022-202X(21)01416-0. •Cell Death Dis. 2021 Apr 30;12(5):426. •Cell Death Dis. 2020 Mar 13;11(3):183. •Stroke. 2018 Oct;49(10):2473-2482. •J Inflamm Res. 2021 Jul 5;14:2955-2962. •Transl Stroke Res. 2021 Dec;12(6):991-1017. •Oxid Med Cell Longev. 19 Oct 2021. •Am J Cancer Res. 2021 May 15;11(5):2062-2080. •Int J Mol Sci. 2019 Nov 24;20(23):5896. •Front Pharmacol. 2021 May 10;12:670224. •Front Pharmacol. 2019 Sep 3;10:968. •J Cell Sci. 2021 Dec 3;jcs.258910. •J Agric Food Chem. 2020 Feb 5;68(5):1326-1336. •J Agric Food Chem. 2019 Sep 25;67(38):10637-10645. •Front Physiol. 2019 Jan 15;9:1922. •Drug Des Devel Ther. 2019 Jul 2;13:2135-2144. •Arch Biochem Biophys. 2021 Aug 23;711:109015. •Research Square Preprint. 2021 May. •Research Square Preprint. 2021 Jan. •bioRxiv. 2020 Dec 14.
纯度及产品资料	98%

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