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抑制剂/激活剂

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凋亡与自噬

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ANA 12

ANA-12 是一种选择性 TrkB 拮抗剂，对高亲和位点和低亲和位点的Kd 分别为10 nM 和 12 μM。

货号：
TK0381
规格：

1mg

2mg

10mg

50mg
价格：
￥0.00

产品参数

CAS No.	219766-25-3
生物活性	ANA-12 is a potent and selective TrkB antagonist with IC50s of 45.6 nM and 41.1 μM for the high and low affinity sites, respectively.
分子式	C22H21N3O3S
分子量	407.49
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder, -20°C ,3 years
溶解性数据	DMSO : 9.09 mg/mL (22.31 mM; Need ultrasonic),Ethanol : < 1 mg/mL (ultrasonic) (insoluble)
体内研究	ANA-12 (0.5 mg/kg, i.p.) partially inhibits the total endogenous TrkB activity in the whole brain of mice. ANA-12, injected in mice, demonstrates anxiolytic and antidepressive activities at 0.5 mg/kg. ANA-12 (0.5, 1.0, and 2.0 mg/kg) does not affect neuron survival. ANA-12 (0.5 mg/kg) shows antidepressant effects in lipopolysaccharide (LPS)-induced depression-like behavior. ANA-12 (0.5 mg/kg) significantly attenuates an increased immobility time in depressed mice. In the TST, FST, and SPT, ANA-12 (0.5 mg/kg) does not show antidepressant-like effects in the control mice. ANA-12 (0.5 mg/kg, i.p.) reverses the diminished self-administration of cocaine in CocSired rats.
体外研究	ANA-12 (10 nM) prevents BDNF-induced neurite outgrowth in the TrkB-expressing cells, and completely abolishes the effects of BDNF at concentrations up to 10-100 μM.
纯度及产品资料	98%

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