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抑制剂/激活剂

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凋亡与自噬

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Cyclosporin A 环孢霉素A；环孢素A；环孢多肽A；环孢灵；赛斯平；环孢素

Cyclosporin A, 一种非极性环寡肽，是一种免疫抑制剂，与亲环素结合，随后抑制calcineurin，无细胞试验中IC50为7 nM，广泛用于预防器官移植反应中的排斥反应,并已用于在灌注的3D近端小管模型上测试其毒性作用。Cyclosporin A (NSC 290193) 可用于诱导肝移植慢性排斥反应动物模型。

货号：
TK0364
规格：

25mg

100mg

200mg

500mg
价格：
￥0.00

产品参数

CAS No.	59865-13-3
生物活性	Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 adhesion.
分子式	C62H111N11O12
分子量	1202.61
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder, -20°C ,3 years
溶解性数据	DMSO : 62.5 mg/mL (51.97 mM; Need ultrasonic)，Ethanol : 50 mg/mL (41.58 mM; Need ultrasonic)
体内研究	Cyclosporin A has immunosuppressive activity, and is active via parenteral and p.o. administration in mice, rat and guinea pigs. Cyclosporin A can be used in organ transplantation to prevent rejection.
体外研究	Cyclosporin A is able to bind with the cyclophilin in T cells. Cyclosporin A works by forming a Cyclophilin-Cyclosporin A complex to inhibit calcineurin. Cyclosporin A inhibits calcineurin in stimulated cells with an IC50 value of 7 nM. Cyclosporin A suppresses the nuclear translocation of NF-AT. Cyclosporin A shows an effect on mitochondria via preventing the MTP from opening with an IC50 of 39 nM.
纯度及产品资料	98%

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