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抑制剂/激活剂

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凋亡与自噬

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SR 11302

SR 11302是一种激活蛋白-1（AP-1）转录因子抑制剂。该视黄醇类化合物能特异性抑制AP-1活性，且不会激活视黄酸反应元件（RARE）的转录。

货号：
TK0359
规格：

5mg
价格：
￥0.00

产品参数

CAS No.	160162-42-5
生物活性	SR 11302 is an activator protein-1 (AP-1) transcription factor inhibitor. SR 11302 is a retinoid that specifically inhibits AP-1 activity without activating the transcription of retinoic acid response element (RARE).
分子式	C26H32O2
分子量	376.53
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : 100 mg/mL (265.58 mM; Need ultrasonic)
体内研究	SR 11302 (SR11302; low dose 0.5 mg/kg and high dose 1 mg/kg body weight; orally gavaged daily) treatment reduces the total vascular lesion number and lesion size in Vldlr mice in a dose-dependent manner.
体外研究	SR 11302 (SR11302) show strong anti-AP-1 activity with selective binding with RARα and RARγ, but not with RARβ and RXRα. SR 11302 (SR-11302; 1 μM) inhibits AP-1 transcription factor activity and decreases aldosterone levels by 61.9% in hypoxia-treated cells. SR 11302 (SR-11302; 2 µM; 48 hours) inhibits Helicobacter pylori (H. pylori)-induced cell proliferation in adenocarcinoma gastric (AGS) cells. SR 11302 (2 µM; 24 hours) inhibits H. pylori-induced expression of β-catenin and c-myc in AGS cells.
文献	•Vet Microbiol. 2021, 109061.
纯度及产品资料	98%

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