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Caspofungin Acetate

Caspofungin Acetate MK-0991 Acetate; L-743872 Acetate

Caspofungin Acetate (MK-0991 Acetate) 是一种抗真菌药，能够非竞争性地抑制 1,3-β-D 葡聚糖合酶的合成。

货号：
TK0353
规格：

1mg

5mg

10mg

25mg
价格：
￥0.00

产品参数

CAS No.	179463-17-3
生物活性	Caspofungin Acetate (MK-0991 Acetate) is an antifungal drug, and noncompetitively inhibits 1,3-β-D glucan synthase activity.
分子式	C52H88N10O15.2[C2H4O2]
分子量	1213.42
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	-20°C, sealed storage, away from moisture and light
溶解性数据	H2O : ≥ 100 mg/mL (82.41 mM) DMSO : 100 mg/mL (82.41 mM; Need ultrasonic)
体内研究	Mice injected with caspofungin at vitreal concentrations from 0.41 to 4.1 μM do not have significant alterations in their ERG waveforms, and their retinas have no detectable morphologic changes or loss of cells. At the vitreal concentration of 41 μM, caspofungin reduces the amplitudes of the a-waves, b-waves, and scotopic threshold responses of the ERG and also produces a decrease in the number of cells in the ganglion cell layer. Caspofungin (8 mg/kg) or amphotericin B at 1 mg/kg given i.p. once daily for 7 days beginning at 30 h after infection resulted in 100% survival through day 28 relative to vehicle control treatment, which results in 100% mortality by day 11 after infectious challenge. Caspofungin reduces recovery of viable Candida from kidney and brain tissues compared to vehicle control treatment on day 5, when control burden peaked. Caspofungin-treated mice dosed with 2 mg/kg or greater have significantly lower brain burden than amphotericin-B-treated mice at day 5. Amphotericin B and caspofungin treatment reduce kidney fungal burden by 1.7 log CFU/g and 2.46 to 3.64 log CFU/g, respectively.
文献	•Cell Physiol Biochem. 2016 Aug 12;39(3):939-949.
纯度及产品资料	98%

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