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抑制剂/激活剂

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凋亡与自噬

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Piperlongumine 荜茇酰胺; Piplartine

Piperlongumine (PPLGM, Piplartine)，存在于胡椒科植物荜茇中的一种天然生物碱，能够增加reactive oxygen species (ROS)水平，并选择性杀死癌细胞。它还是TrxR1的直接抑制剂，对胃癌具有抑制活性；一种新型的CRM1抑制剂；在人类乳腺癌细胞中可抑制PI3K/Akt/mTOR。

货号：
TK0349
规格：

10mg
价格：
￥0.00

产品参数

CAS No.	20069-09-4
生物活性	Piperlongumine is a alkaloid, possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, antitumor, and antidiabetic activities. Piperlongumine induces ROS, and induces apoptosis in cancer cell lines. Piperlongumine shows anti-cardiac fibrosis activity, suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway.
分子式	C17H19NO5
分子量	317.34
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : 100 mg/mL (315.12 mM; Need ultrasonic)
体内研究	Piperlongumine (30 mg/kg/day, i.p. for 3 weeks) exhibits potent anti-tumor effect in athymic nude mice bearing L3.6pL cells without body weight loss.
体外研究	Piplartine (5, 10, and 15 μM) significantly decreases cell proliferation of 786-O, SKBR3, Panc1, A549, and L3.6pL cancer cells after treatment for 24 and 48 hours, induces apoptosis and ROS in these cell lines at 5 and 10 μM after 3 or 9 h of treatment. Piplartine (5 or 10 μM) induces cleaved PARP and downregulates Sp1, Sp3, Sp4, and Sp-regulated genes. Piplartine (20 μM) decreases the viability of cardiac fibroblasts (CFs). Piplartine (0-10 μM) suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway.
纯度及产品资料	98%

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