Zinc Protoporphyrin (Zn(II)-protoporphyrin IX)是一种有效的、具有口服活性和竞争性的 血红素加氧酶-1(heme oxygenase-1, HO-1)抑制剂，可显着降低间苯三酚(Phloroglucinol, PG)对过氧化氢的保护作用。此产品溶解度不佳，动物实验可用，细胞实验请谨慎选择！
| CAS No. | 15442-64-5 |
| 生物活性 | Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2. Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration. Zinc Protoporphyrin has anti-cancer activity. |
| 分子式 | C34H32N4O4Zn |
| 分子量 | 626.02 |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存条件 | （-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| 溶解性数据 | DMSO : 20.83 mg/mL (33.27 mM; ultrasonic and warming and heat to 80°C) |
| 体内研究 | Zinc Protoporphyrin (12.5, 25, 50 mg/kg for i.p.; 12.5, 50 mg/kg for p.o.; from day 7 to 19) exerts dose-dependent antitumor effects manifested by the retardation of tumor growth. |
| 体外研究 | Zinc Protoporphyrin (Zn(II)-protoporphyrin IX; 5 μM; 72 hours) causes the fraction of late apoptotic and necrotic cells increasing from 10.9% in controls to 30.4% after 72 h. Zinc Protoporphyrin (1.25-40 μM; 48 or 72 hours) exerts cystostatic/cytotoxic effects against tumor cells. Zinc Protoporphyrin (2.5, 5 μM; 48 or 72 hours) results in dose- and time-dependent reduction of cells in G1 phase of the cell cycle. Zinc Protoporphyrin (1.25-40 μM; 48 hours) leads to accumulation of cleaved (active) caspase-3. |
| 纯度及产品资料 | ≥98% |
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