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抑制剂/激活剂

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凋亡与自噬

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Fludarabine 氟达拉滨; F-ara-A; NSC 118218

Fludarabine在血管平滑肌细胞中是一种STAT1活化抑制剂，特异性降低STAT1蛋白质水平（和mRNA水平），而对其他STATs无此作用。它还是一种DNA合成抑制剂。Fludarabine可诱导凋亡。

货号：
TK0327
规格：

1mg

5mg

10mg
价格：
￥0.00

产品参数

CAS No.	21679-14-1
生物活性	Fludarabine (NSC 118218) is a DNA synthesis inhibitor and a fluorinated purine analogue with antineoplastic activity in lymphoproliferative malignancies. Fludarabine inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes.
分子式	C10H12FN5O4
分子量	285.23
储存条件	Powder -20℃ 3 years
溶解性数据	DMSO : 25 mg/mL (87.65 mM; Need ultrasonic)
体内研究	Fludarabine (0.8 mg/kg; i.p.; two cycles for 5 days every 2 weeks) in combination with Cyclophosphamide (400 mg/kg; i.p.; 2 weeks) decreases incidence of GVHD.
体外研究	Fludarabine (5 μM; 48 hours) induces a decrease in p27kip1 expression.
文献	暂无相关参考文献
纯度及产品资料	98%

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