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抑制剂/激活剂

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凋亡与自噬

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Cilengitide CP-456773 sodium; CRID3 sodium salt

Cilengitide (EMD 121974, EMD-12192, EMD-85189, NSC-707544) 是一种有效的、选择性的 integrins ανβ3 和 ανβ5 的抑制剂，对应的IC50值分别为 4 nM和 79 nM。

货号：
TK0322
规格：

1mg

2mg

5mg

10mg
价格：
￥0.00

产品参数

CAS No.	188968-51-6
生物活性	Cilengitide (EMD 121974) is a potent and selective inhibitor of the integrins ανβ3 and ανβ5. Cilengitide inhibits binding of isolated ανβ3 and ανβ5 to Vitronectin with an IC50 value of 4 and 79 nM, respectively .
分子式	C27H40N8O7
分子量	588.66
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
体内研究	Cilengitide (i.p. at 10, 50, and 250 μg three times per week) inhibits M21-L melanoma tumors growth in nude mice .
体外研究	Cilengitide is a cyclized RGD (Arg-Gly-Asp motif)-containing pentapeptide. Cilengitide blocks integrin ανβ3- and ανβ5-mediated endothelial cell attachment and migration. Cilengitide inhibits integrin-mediated binding to Vitronectin with IC50's of 0.4 and 0.4 μM in cell adhesion studies assessing the human melanoma M21 or UCLA-P3 human lung carcinoma cell lines . Cilengitide inhibits the attachment of human umbilical vein endothelial cells to Vitronectin with an IC50 of 2 μM .
文献	•Cell. 2020 Aug 6;182(3):545-562.e23. •Cancer Cell. 2021 Sep 28;S1535-6108(21)00492-X. •Nat Cell Biol. 2020 Mar;22(3):289-296. •J Immunother Cancer. 2020 Mar;8(1):e000111. •Clin Transl Med. 2021 Oct;11(10):e548. •Front Immunol. 2018 Jun 1;9:1207. •Engineering. 8 October 2020. •Stem Cell Reports. 2017 Dec 12;9(6):1948-1960. •Front Pharmacol. 2021 Feb 24;12:585778. •J Transl Med. 2018 Dec 12;16(1):352. •Cancer Med. 2018 Feb;7(2):408-419. •Am J Physiol Cell Physiol. 2018 Apr 1;314(4):C415-C427. •Obesity. 2015 Apr;23(4):779-85. •Cell Biol Int. 2020 Apr;44(4):966-974. •Biomed Res Int. 30 Nov 2021. •PLoS One. 2016 Feb 3;11(2):e0148333. •PLoS One. 2014 Oct 13;9(10):e110453. •J Mol Histol. 2020 Apr;51(2):147-159. •Lung. 2020 Dec;198(6):947-955. •Scand Cardiovasc J. 2021 Jul 23;1-10. •bioRxiv. 2020 Apr. •Cell Adh Migr. 2019 Jan 21:1-12. •Patent. US20180263995A1. •Department of Bioengineering. Santa Clara University. Jun 12, 2014 .
纯度及产品资料	98%

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