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抑制剂/激活剂

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凋亡与自噬

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Cyclo(-RGDfK) TFA

Cyclo(-RGDfK) TFA

Cyclo(-RGDfK) TFA 是有效，选择性的整合素 αvβ3 抑制剂，其 IC50 值为 0.94 nM。Cyclo(-RGDfK) TFA 通过与细胞表面的 αvβ3 整合素结合，特异性靶向肿瘤微血管和癌细胞。

货号：
TK0299
规格：

1mg

5mg
价格：
￥0.00

产品参数

CAS No.	500577-51-5
生物活性	Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM. Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface.
分子式	C29H42F3N9O9
分子量	717.69
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -80°C 2 years
溶解性数据	DMSO : 100 mg/mL (139.34 mM; Need ultrasonic) H2O : 33.33 mg/mL (46.44 mM; Need ultrasonic)
体外研究	Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin and exhibits a IC50 of 0.94 nM. [Ga]DOTA-E-[c(RGDfK)]2 can be prepared with high radiochemical purity (>97%), specific activity (36-67GBq/μM), in vitro stability, and moderate protein binding. MicroPET imaging up to 24 post-injection showed contrasting tumors reflecting αvβ3-targeted tracer accumulation.
文献	•Bioact Mater. 6 (2021) 2039-2057. •Adv Healthc Mater. 2021 May 29;e2100304. •ACS Appl Mater Interfaces. 2019 Jul 31;11(30):26648-26663. •Acta Biomater. 2021 Mar 9;S1742-7061(21)00152-5. •Mol Ther Nucleic Acids. 2021 Jan 9;23:797-810. •Engineering. 8 October 2020.
纯度及产品资料	98%

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