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抑制剂/激活剂

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凋亡与自噬

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Gap 27

Gap 27，一种合成的 connexin43 模拟肽，是一种间隙连接抑制剂。Gap 27 与通往第二跨膜连接蛋白区段的第二细胞外环的一部分具有保守的序列同源性。

货号：
TK0298
规格：

1mg

2mg

5mg
价格：
￥0.00

产品参数

CAS No.	198284-64-9
生物活性	Gap 27, a synthetic connexin43 mimetic peptide, is a gap junction inhibitor. Gap 27 possesses conserved sequence homology to a portion of the second extracellular loop leading into the fourth transmembrane connexin segment.
分子式	C60H101N15O17
分子量	1304.53
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -80°C 2 years
溶解性数据	H2O : 33.33 mg/mL (25.55 mM; Need ultrasonic)
体内研究	Gap 27 (300 μM) inhibits relaxation by 40% in thoracic aorta and the superior mesenteric artery. Gap 27 also attenuates the endothelium-dependent component of the relaxation induced by ATP in thoracic aorta. .
体外研究	Gap 27 causes a remarked decrease in the number of both TRAP-positive mononuclear and multinucleated rat osteoclasts cultured on bovine bone slices. The activity of the remaining osteoclasts is found to be diminished by measuring the percentage of osteoclasts with actin rings of all TRAP-positive cells. In addition, the resorbed area in the treated cultures is greatly diminished. Incubation of the carotid artery with the gap junction inhibitor Gap 27 (500 μM) essentially abolishes the hyperpolarization to acetylcholine but it is without effect on that to levcromakalim. In the guinea-pig isolated internal carotid artery, Gap 27 inhibits acetylcholine-induced, endothelium-dependent hyperpolarizations.
文献	•Cell Biol Toxicol. 2021 Jul 20. •Front Cell Dev Biol. 2021 Jun 8;9:637233.
纯度及产品资料	98%

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