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Vincristine sulfate

Vincristine sulfate 硫酸长春新碱; Leurocristine sulfate; NSC-67574 sulfate; 22-Oxovincaleukoblastine sulfate

Vincristine sulfate是一种抗肿瘤长春花生物碱，抑制有丝分裂纺锤体中的 microtubule 形成，导致中期阶段的分裂细胞停滞。它与 microtubule 结合的 Ki 为85 nM。

货号：
TK0294
规格：

1mg

5mg

10mg

50mg

100mg
价格：
￥0.00

产品参数

CAS No.	2068-78-2
生物活性	Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of 85 nM.
分子式	C46H58N4O14S
分子量	923.04
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	4°C, protect from light
溶解性数据	DMSO : 83.33 mg/mL (90.28 mM; ultrasonic and warming and heat to 80°C) H2O : 50 mg/mL (54.17 mM; Need ultrasonic)
体内研究	Vincristine (3 mg/kg, i.p.) induces mean growth delay of > 120 and > 52 day, and repopulates fractions of 0.06% and 5%, administrated in mice bearing bilateral subcutaneous xenografts Rh12 or Rh18, respectively.
体外研究	Vincristine inhibits net addition of tubulin dimers at assembly ends of steady-state microtubules with Ki of 85 nM. Vincristine stabilizes the spindle apparatus resulting in failure of the chromosomes to segregate leading to metaphase arrest and inhibition of mitosis at low concentrations. At higher concentrations, Vincristine may disrupt and induce total depolymerization of microtubules. Vincristine induces apoptosis in tumor cells and inhibits SH-SY5Y cell proliferation with IC50 of 0.1 μM. Vincristine induces mitotic arrest and promots the expression of caspase-3 and -9 and cyclin B, while decreasing the expression of cyclin D. Vincristine induced neurotoxicity is caused by interference with microtubule function, which results in blockage of axonal transport and thus in axonal degeneration.
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纯度及产品资料	98%

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