>>

>>

抑制剂/激活剂

>>

凋亡与自噬

>>

5-Azacytidine 5-氮杂胞苷; Azacitidine; 5-AzaC; Ladakamycin

Azacitidine (5-Azacytidine, 5-AzaC, Ladakamycin, AZA, 5-Aza, CC-486,NSC 102816) 是胞苷的核苷类似物，通过捕获DNA甲基转移酶，特异性抑制DNA甲基化。Azacitidine可诱导线粒体凋亡与自噬。

货号：
TK0269
规格：

100mg

200mg

500mg
价格：
￥0.00

产品参数

CAS No.	320-67-2
生物活性	5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases and contributes to reverse epigenetic changes. 5-Azacytidine induces cell autophagy.
分子式	C8H12N4O5
分子量	244.2
储存条件	Powder -20℃ 3 years
溶解性数据	H2O : 25 mg/mL (102.38 mM; ultrasonic and warming and heat to 60°C) DMSO : ≥ 31 mg/mL (126.95 mM)
体内研究	TdR-H incorporation is significantly inhibited when the animals are exposed to 5-Azacitidine (100 mg/kg, i.p.) for 2 hr or longer.
体外研究	Unmethylated CpG islands associated with a variety of genes become partially or fully methylated in tumors and can be reactivated by 5-Azacytidine. 5-Azacytidine acts as weak inducers of erythroid differentiation of Friend erythroleukemia cells in the same concentration range where they affect DNA methyltransferase activity. 5-Azacytidine inhibits L1210 cells with ID50 and ID90 values of 0.019 and circa 0.15 μg/mL, respectively.
文献	暂无相关参考文献
纯度及产品资料	98%

推荐产品