Doxorubicin 阿霉素;羟基柔红霉素;亚法里亚霉素;羟基红比霉素;14-羟正定霉素;多柔比星;阿霉素,BR;阿霉素盐酸盐;多柔比星标准品;10-((3-氨基-2,3,6-三去氧-alpha-L-来苏-己吡喃基)氧)-7,8,9,10-四氢-6,8,11-三羟基-8-羟乙酰基-1-甲氧基-5,12-萘二酮

Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. Doxorubicin intercalates into DNA double strand and inhibits the progression of DNA topoisomerase II, stopping replication process. Doxorubicin also induces histone eviction from open chromatin, causing DNA damage and epigenetic deregulation. Doxorubicin is administrated intravenously. Approximately 75% of doxorubicin and its metabolites bind to plasma protein. Doxorubicin does not cross blood brain barrier. 50% of the drug is eliminated unchanged from the body mainly though bile excretion. The remaining undergoes one-electron reduction, two-electron reduction, and deglycosidation. The major metabolite is a potent membrane ion pump inhibitor, which is associated with cardiomyopathy.