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抑制剂/激活剂

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凋亡与自噬

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Ro5-3335

Ro5-3335 是一种苯二氮化合物，能作为核心结合因子 (CBF) 白血病抑制剂。Ro5-3335 是 RUNX1-CBFβ 相互作用抑制剂，可抑制 RUNX1/CBFB 依赖性反式激活。

货号：
TK0256
规格：

1mg

2mg

5mg
价格：
￥0.00

产品参数

CAS No.	30195-30-3
生物活性	Ro5-3335, a benzodiazepine, acts as an inhibitor of core binding factor (CBF) leukemia. Ro5-3335 is a RUNX1-CBFβ interaction inhibitor that represses RUNX1/CBFB-dependent transactivation.
分子式	C13H10ClN3O
分子量	259.69
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : 100 mg/mL (385.07 mM; Need ultrasonic)
体内研究	Ro5-3335 is identified as an inhibitor of RUNX1–CBFβ function in zebrafish models. Ro5-3335 rescues preleukemic phenotype in a RUNX1-ETO transgenic zebrafish. Ro5-3335 (300 mg/kg/d; p.o; for 30 days) reduces leukemia burden in a mouse CBFB-MYH11 leukemia model.
体外研究	Ro5-3335 has antiproliferative activity against human CBF leukemia cell lines, with IC50s of 1.1 μM, 21.7 μM and 17.3 μM for ME-1, Kasumi-1 and REH, respectively. Ro5-3335 inhibits definitive hematopoiesis in zebrafish embryos. Ro5-3335 does not completely break apart RUNX1-CBFβ interaction, but changes the conformation of their complex or increases the distance between RUNX1 and CBFβ in the complex.
纯度及产品资料	98%

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