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抑制剂/激活剂

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凋亡与自噬

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Camptothecin 喜树碱; Campathecin; (S-(+)-Camptothecin; CPT)

Camptothecin (CPT)，一种生物碱，是一种 DNA topoisomerase I (Topo I) 抑制剂，其 IC50 值为 679 nM。Camptothecin (CPT) 对结直肠癌、乳腺癌、肺癌和卵巢癌具有强大的抗肿瘤活性，通过改变人类癌细胞中的 miRNA 表达模式来调节 hypoxia-inducible factor-1α (HIF-1α) 活性。

货号：
TK0238
规格：

20mg

50mg

100mg

500mg
价格：
￥0.00

产品参数

CAS No.	7689-03-4
生物活性	Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells.
分子式	C20H16N2O4
分子量	348.35
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	4°C, protect from light
溶解性数据	DMSO : 6.25 mg/mL (17.94 mM; Need ultrasonic)
体内研究	Camptothecin (2 mg/kg every other day) treats mice, has developed numerous pulmonary metastases. Treatment with both kinase inhibitor of nuclear factor-kappaB-1 (KINK-1) and Camptothecin led to a statistically significant reduction in the number of pulmonary metastases.
体外研究	High TOP1 enzymatic activity MCF7 (Luminal subtype) and HCC1419 (HER2 subtype) show high sensitivity toward Camptothecin (0.1 μM to 5 μM; 72 hours) treatment, exhibiting the IC50 values of 0.089 μM and 0.067 μM, respectively. Camptothecin (0.5 μM; 6 and 24 hours) reduces desferrioxamine-activated VEGF expression. Camptothecin (0.5 μM; 8 to 24 hours) strongly prevents the desferrioxamine-dependent HIF-1a accumulation.
文献	•Autophagy. 2021 Mar 22;1-17. •Cell Death Differ. 2020 Nov;27(11):3162-3176. •Nat Commun. 2021 Aug 16;12(1):4961. •Nat Commun. 2019 Aug 21;10(1):3761. •Nat Commun. 2018 Oct 8;9(1):4139. •Gene Dis. 2019 May 25;7(3):401-407. •Cells. 2019 Oct 15;8(10):1258. •Int J Biol Sci. 2015 Aug 8;11(10):1181-9. •J Cell Physiol. 2019 Mar;234(3):2683-2692. •J Transl Med. 2016 Mar 15;14:73. •PLoS Genet. 2019 Feb 4;15(2):e1007925. •J Mol Med (Berl). 2019 Aug;97(8):1183-1193. •Int J Mol Med. 2019 Jun;43(6):2491-2498. •Exp Cell Res. 2020 Sep 15;394(2):112148. •Cell Biol Int. 2020 Aug;44(8):1640-1650. •Biochem Biophys Res Commun. 2018 Sep 3;503(1):297-303. •Toxicol In Vitro. 2020 Jun;65:104825. •Toxicol In Vitro. 2017 Apr 19;42:130-138. •Exp Ther Med. 2021 Mar 18. •Biosci Biotechnol Biochem. 2021 Dec 16;zbab215. •Health Science Journal. August 31, 2021. •Patent. US20210009719A1. •bioRxiv. 2019 Apr.
纯度及产品资料	98%

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