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抑制剂/激活剂

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凋亡与自噬

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Flavopiridol 夫拉平度; HMR-1275; Alvocidib; L86-8275

Flavopiridol (Alvocidib) 是一种竞争型的 CDK 广谱抑制剂，抑制 CDK1，CDK2，CDK4的IC50 分别为30，170，100 nM。

货号：
TK0234
规格：

1mg

5mg

10mg

50mg
价格：
￥0.00

产品参数

CAS No.	146426-40-6
生物活性	Flavopiridol (Alvocidib) is a broad spectrum and competitive inhibitor of CDKs, inhibiting CDK1, CDK2, CDK4 with IC50s of 30, 170, 100 nM, respectively.
分子式	C21H20ClNO5
分子量	401.84
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	4°C, stored under nitrogen
溶解性数据	DMSO : 33.33 mg/mL (82.94 mM; Need ultrasonic)
体外研究	Flavopiridol (2 μM) robustly induces a distinct pattern of ER stress in CLL cells that contributes to cell death through IRE1-mediated activation of ASK1 and possibly downstream caspases. Flavopiridol results in potent upregulation of a number of PRGs in treatments lasting 4-24 h. Flavopiridol has and immediate and long-term effect on the expression of several PRGs. In serum starved cells re-stimulated with serum, flavopiridol also inhibits the expression of these genes, but subsequently, JUNB, GADD45B and EGR1 are upregulated in the presence of flavopiridol. Flavopiridol (Alvocidib) also inhibits cyclin E1 and induces apoptosis.
文献	•Cell. 2021 Apr 15;184(8):2167-2182.e22. •Cancer Discov. 2021 Oct 6;candisc.1848.2020. •Sci Transl Med. 2018 Jul 18;10(450). pii: eaaq1093. •Biomaterials. 2014 Aug;35(24):6585-94. •Proc Natl Acad Sci U S A. 2021 Nov 16;118(46):e2115667118. •Clin Cancer Res. 2020 Apr 15;26(8):2011-2021. •Cell Rep. 2020 Apr 28;31(4):107586. •Cell Mol Life Sci. 2020 May 21. •Cell Syst. 2018 Apr 25;6(4):424-443.e7. •Cell Chem Biol. 2019 Aug 15;26(8):1067-1080.e8. •Cell Chem Biol. 2018 Feb 15;25(2):135-142.e5. •J Med Chem. 2021 Feb 23. •ACS Chem Biol. 2017 May 19;12(5):1245-1256. •Sci Rep. 2021 Mar 8;11(1):5374. •Sci Rep. 2015 Dec 1;5:17675. •Biochem Biophys Res Commun. 2019 Jun 11;513(4):967-973. •Turk Neurosurg. 2016;26(6):922-929. •Research Square Preprint. 2022 Jan. •Free University of Berlin. Gedruckt mit Genehmigung des Fachbereichs Veterinärmedizin. 2021 Mar. •School of Medicine, Department of Pharmacology. 2020 Jun. •Harvard Medical School LINCS LIBRARY
纯度及产品资料	98%

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