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抑制剂/激活剂

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凋亡与自噬

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Hydroxyurea Hydroxycarbamide

Hydroxyurea 通过抑制核糖核苷酸还原酶抑制 DNA 合成的细胞凋亡诱导剂。

货号：
TK0231
规格：

500mg

1g

5g
价格：
￥0.00

产品参数

CAS No.	127-07-1
生物活性	Hydroxyurea is a cell apoptosis inducer that inhibit DNA synthesis through inhibition of ribonucleotide reductase.
分子式	CH4N2O2
分子量	76.05
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : 50 mg/mL (657.46 mM; Need ultrasonic) H2O : 50 mg/mL (657.46 mM; Need ultrasonic)
体内研究	Hydroxyurea therapy producs consistent reductions in WBC and ANC without improvement in anemia over 17 weeks. Hydroxyurea at 50mg/kg produces a reduced white blood cell count, absolute neutrophil count and no improvement in anemia compared to vehicle treated sickle cell mice.
体外研究	Hydroxyurea is used in a number of myeloproliferative, neoplastic, HIV, and non-hematological diseases. Treatment of cells in primary culture with 30 μM hydroxyurea for 96 hours significantly increases the fractional HbF content. The γ: γ-globin mRNA is induced 0.30- to 8-fold in vitro. Hydroxyurea has been shown to block HIV-1 reverse transcription and/or replication in quiescent peripheral blood mononuclear cells and macrophages.
文献	•Cell Death Dis. 2020 Nov 12;11(11):976. •Cell Death Dis. 2020 Jun 15;11(6):464. •J Cell Mol Med. 2019 Oct;23(10):6797-6804. •J Mol Med (Berl). 2019 Aug;97(8):1183-1193. •Arch Biochem Biophys. 2020 Nov 15;694:108601.
纯度及产品资料	98%

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